Journal: Sleep

Article Title: Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults

doi: 10.1093/sleep/zsab191

Figure Lengend Snippet: Slow wave events increase in amplitude after learning only in CC carriers. (A) EEG electrodes were placed in standard locations according to the 10−20 system. (B) SW wave-triggered average at electrode F3 during N3 sleep for both genotype groups and recording nights. CC, baseline night, grey, CC, learning night, black, AA baseline night, light blue, AA learning night, dark blue. We found no difference for any time bin ( p < 0.05, Wilcoxon rank sum test, no correction). (C1−4) Topography plots of SW amplitudes at all recorded EEG electrodes for both genotype groups and recording nights. (D) Estimated marginal means differences for the factors genotype and night derived from a linear mixed model analysis of all detected SW amplitudes (see Methods for details). The CC group show an increase in SW amplitude during night 2, but AA do not. Error bars indicate 95% confidence intervals.

Article Snippet: Behavioral measures were analyzed either by a comparison of means across groups (two-sample two-sided t -test or Wilcoxon rank-sum test) or by fitting a LMM with genotype and MST session (training versus testing) fitted as fixed effects, participant identity was fitted as a random effect (using Stata v14.2 [ ]).

Techniques: Derivative Assay

Journal: Sleep

Article Title: Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults

doi: 10.1093/sleep/zsab191

Figure Lengend Snippet: Slow wave coherence. (A) Raw data example showing all EEG traces surrounding a typical SW event at Fz. (B) SW wave-triggered averages from one participant from band pass filtered (0.5−4 Hz) and EEG traces. Individual SW event traces were averaged in windows of ±2 seconds with the SW trough time set t = 0. B1) SW triggered average at Fz and O1 for 51 SW events detected during night 1 N2 sleep in one participant (CC, Night 1), B2) SW triggered averages as described in C1 using, 115 SW events during night 2 from the same participant (‘CC’, Night 2). (C) Average SW triggered coherograms. SW triggered data windows (SW trough time at Fz, t = 0) from the seed electrode (Fz) and target electrode (O1) were used to calculate multitaper coherograms for each data window pair. Coherograms were averaged for each participant and then averaged for each group and recording night. In the coherogram, lighter colors indicate higher coherence. Overlaid black traces are SW wave triggered averages for seed and target electrode (Fz, top and O1, bottom). C1) Average coherogram for CC night 1, C2) Average coherogram for CC night 2, C3) Average coherogram for AA night 1, C4) Average coherogram for AA night 2. (D) Average SW-triggered coherence values (0.5−1.5 Hz, −0.5−0.5 s) for all electrode pairs for each genotype group during N2 sleep for both recording nights. (D1) CC, during night 1; (D2) CC, during night 2, (D3) AA, during night 1, D4 AA, during night 2. (E) Differences in SW coherence between nights in each genotype group CC (E1), and AA (E2). (F) Differences between genotype groups on each night, night 1: CC-AA (F1), night 2: CC-AA (F2). (G) Estimated marginal means differences for the factors genotype and night estimated from a linear mixed model analysis of SW event coherence. CC individuals show an increase in SW coherence during night 2, but AA’s show an overall decrease in coherence. Error bars indicate 95% confidence intervals.

Article Snippet: Behavioral measures were analyzed either by a comparison of means across groups (two-sample two-sided t -test or Wilcoxon rank-sum test) or by fitting a LMM with genotype and MST session (training versus testing) fitted as fixed effects, participant identity was fitted as a random effect (using Stata v14.2 [ ]).

Techniques:

Journal: Sleep

Article Title: Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults

doi: 10.1093/sleep/zsab191

Figure Lengend Snippet: Overview of statistical analysis of non-EEG data

Article Snippet: Behavioral measures were analyzed either by a comparison of means across groups (two-sample two-sided t -test or Wilcoxon rank-sum test) or by fitting a LMM with genotype and MST session (training versus testing) fitted as fixed effects, participant identity was fitted as a random effect (using Stata v14.2 [ ]).

Techniques: Sequencing, Comparison

Journal: Sleep

Article Title: Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults

doi: 10.1093/sleep/zsab191

Figure Lengend Snippet: Overview of statistical analysis of sleep EEG data

Article Snippet: Behavioral measures were analyzed either by a comparison of means across groups (two-sample two-sided t -test or Wilcoxon rank-sum test) or by fitting a LMM with genotype and MST session (training versus testing) fitted as fixed effects, participant identity was fitted as a random effect (using Stata v14.2 [ ]).

Techniques: Derivative Assay

Journal: Sleep

Article Title: Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults

doi: 10.1093/sleep/zsab191

Figure Lengend Snippet: Linear mixed model analysis of MST performance across groups and sessions

Article Snippet: Behavioral measures were analyzed either by a comparison of means across groups (two-sample two-sided t -test or Wilcoxon rank-sum test) or by fitting a LMM with genotype and MST session (training versus testing) fitted as fixed effects, participant identity was fitted as a random effect (using Stata v14.2 [ ]).

Techniques: